In reference to a lengthy post previously written by John L. Hinnant on this subject: His thinking was that the 1 in 66" twist barrels are among the best for obtaining high velocity accuracy with a patched round ball. He stressed that while this twist can also be very accurate with lighter powder loads, he found that its best accuracy often resulted from shooting PRB's at higher velocities.
My guess would be that the low end of "higher velocity" powder charges might be in the 65-70 grain range, although lighter powder charges might shoot just fine too. This can depend on the depth of your barrel's rifling, the size of your ball and patch combination and type of powder, etc... :thumbsup: