I've never done it, but you've got me curious: Is that a .36 or a .44? Do you 'bark' the critter the way you do with a flinter smokepole, (that I've done), or are you making headshots? How close?
That's a Pietta .36 and it's zeroed to shoot point of aim at 15 yards. Normally, I carry it while hunting with my percussion SXS or .36 long rifle for shots that are too close to use the long guns on. That particular squirrel was taken at about 15 feet and was a headshot (which is why the head is not visible in the photo).
I've taken numerous squirrels and rabbits with that pistol and one red fox at about 10 yards!