There are a couple of factors at play here. Black powder burns most consistently with a certain amount of settling & compression, and this has been extensively explored in the context of BPCR and percussion precision shooting. Ignition can be a different matter. Percussion ignition systems ignite the powder with a jet of high-pressure incandescent gasses that will blow through the powder more-or-less regardless of the compression. In contrast, Flintlocks (matchlocks, wheellocks, etc.) ignite best when the powder that is exposed to the flash, and the nearby powder grains that are ignited before pressure has built up, are NOT compressed, so that they retain maximum permeability to the initially-low-pressure incandescent gasses flowing through them. The late Forum member Paul Vallandingham reported fairly comprehensive tests with plain-breeched flint and cap rifles, and found that he consistently got the lowest standard deviation of the muzzle velocity in caplocks with a certain amount of compression, but in flintlocks with the ball just touching the powder and no compression. This ignition sensitivity was a major factor in the development of the various patent and non-patent chambered breeches in the late 18th and early 19th centuries. If the chamber has suitable size and shape, compression of the charge will stop at the chamber as the grains bridge on the mouth of the chamber under compression, leaving the charge in the chamber and flash channel uncompressed. If the chamber is too small, as in some modern reproductions, this bridging can occur when the powder is poured, or might occur more with coarser powder but less with finer. These are the guns, both flintlock and percussion, where one has to slap the stock to settle the powder before ramming the ball down, to prevent misfires. The classic Nock patent breech used a separate transverse second chamber to ensure that the powder initially ignited was uncompressed but shot a high pressure jet up through the center of the primary chamber and the compressed main charge for maximum efficiency.
Regards,
Joel