For precussion rifles which use a side drum which the nipple is screwed into, there is another trick which can almost always eliminate the dreaded "missfire".
The idea behind this is based on two ideas.
First, (as mentioned above) you want the loose powder to blow into the hole which connects the bore with the nipple.
Second, when the cap fires, the flame will travel deeper down the hole connecting the nipple with the bore if it doesn't have to be blowing into a sealed chamber.
These two ideas make the answer easy to understand. You drill a hole between the nipple and the bore.
My 3rd BP rifle was a CVA Hawken. It used a drum on the side of the barrel for the nipple to screw into, and the drum had a hole down the middle into the barrel. This is pritty much standard proceedure for many precussion guns.
Using a 1/16 inch diameter drill, I drilled a hole thru one wall of the drum until it hit the drums center hole.
This hole was pointed forward and upward at about a 45 degree angle from the barrels centerline, and it was located about 3/32 (.093) inch from the side of the barrel flat.
If you try this, be sure to use a good center punch to mark the location or the drill will "walk" all over the place.
Does this new hole effect velocity?--- Sure it does, but not much more than the vent hole does on a flintlock.
Should I add extra powder to make up for the lost gas?---I wouldn't unless you see a marked change in the point of impact on the target. Then maybe less than 5 grains more.
I really don't think you'll see much change.
Is this new hole dangerous?---Not unless you put your finger over it when your firing the gun (not recommended). Notice that the new hole is pointed forward and up, not backwards at the shooter.
Does the precussion cap fragment and blow off like it did before?--- Sometimes it will blow off. Often, the cap will fragment just from the explosion of the priming powder. Expect to have to pry off a cap now and then.
Does it really help? ---As I recall, even loading Pyrodex with the nipple clear and the hammer at half cock, I had about 10% missfires. I even had missfires with black powder. After doing this rework to the drum, that dropped to less than 2% with Pyrodex and none with black powder. I attributed most of those to oil residue in the drum on the first shot of the day.