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Load for a Pedersoli 45 cal flintlock

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Have a couple of .44 LePages but no .45. Here's my 2c:

Believe Pedersoli calls for a .445 ball in their .45's so start there.

Best guess would be a .010" patch and 20gr FFFg to start, working up from there until you hit the sweet spot.
 
Your flintlock needs to use real black powder in the pan and in the barrel.

None of the synthetic black powder replacements will work well, if at all.

The best pistol loads use 3Fg granulation.

Use a patched .440 diameter lead roundball. The patch thickness should be around .010 (ten thousandths thick) and made from linen or cotton cloth.

The powder load can vary from 20 to 45 grains but 20-30 grains will give the most useful loads.
The short barrel really doesn't give loads larger than that enough time to burn.

When Lyman tested a .45 cal. single shot pistol with a 8" barrel, they found that a 20 grain load of GOEX 3Fg gave a muzzle velocity of 924 fps.
At 25 grains the mv increased to 1027 fps and 30 grains gave 1104 fps.
They didn't bother to test larger powder loads in their .45.
 
Smoothbore or rifled? Loads will be very different. With a smoothbore, try 30 grains. Rifled, try 15 and work up in 2 grain increments.

Either way, use Swiss Null B for priming.
 
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