The more powder you have behind a given projectile, the higher the breech pressure is going to be.
The heavier the projectile, the higher the breech pressure is going to be.
The finer the size of the Black Powder grains, the faster it burns so finer powders create pressure faster in a given load at the moment of ignition.
Put any one, or all three of these together and there will be a point reached where the pressure exceeds the barrels ability to contain it.
If this occurs the barrel will blow up, or the breech plug will blow out.
Most Governments outside of the United States require that all guns must pass a proof test to assure that a reasonable load is safe to shoot in the gun.
The United States does not require this test although all companies run proof tests to assure the firearm is safe to shoot.
IMO, most muzzleloading rifles are somewhat overdesigned in this age with our current materials.
I feel this is true because the original designs were made to work fairly safely although they were made out of forge welded wrought iron which could have weak places in it.
These originals were each proof tested to weed out the guns which would be dangerous.
Our modern recreations are made out of much higher quality, stronger material, but the designs haven't changed so putting these things together results in a safe firearm which does not really need to be tested.
This is not to say they are safe with any load because, as I said in the beginning unsafe pressures can be created which could cause the material to fail.
It's just my opinion, but a powder load in excess of 130 grains in a .50 caliber barrel is not only a waste of powder, but could create a dangerous condition.
The smaller caliber barrels maximum powder loads are considerably less.
zonie