In my percussion guns I have loaded the same volumn of FFg and Pyrodex RS and find little if any difference in the point of impact. That is to say, the group size and location on the target was about the same. The only time I have had ignition problems with Pyrodex is when I used some caps which are at least 20 years old. With new caps, no problem.
Pyrodex doesn't work well at all for me when used in my Flintlocks. It usually takes at least 3 panloads of FFFFg before the main charge goes off. (With Blackpowder the ignition rate in the same gun is about 95% so it's not the gun or my loading methods).
I have read that the ignition point for Pyrodex is about 100 degrees hotter than Blackpowder so that could easily explain the flintlocks dislike of it.
With blackpowder I usually get about 6 shots before I need to clean the bore with a damp patch and a dry one. With Pyrodex I can shoot for over 2 hours without wiping the bore once.
No, I don't work for or own stock in Hodgdon. In fact, in my humble opnion (IMHO) their Select isn't as consistant as the RS so I don't know why they charge more for it.
Good Shootin'