I've shot a bushel basket of REALs through an assortment of 54 cal rifles at paper, plus killed a few deer with them. I'm surprised you are having to put so much effort into seating them. With all my 54 rifles and both REALs (300 and 380 grain) seating requies a sharp smack on the short starter, but after than they go down the pipe about as easily as anything else.
For accuracy I've had the best luck putting a felt wad lubed with NL 1000 between them and the charge.
They're fun to shoot and a whole lot more accurate (especially the 380) at long range (200-400 yards) than an RB, but that's purely a paper exercize. I'm not shooting them or RB's further than 100 yards at game, and 75 yards is more like my true field limit. At those ranges the difference in groups between REAL and PRB aren't enough to think about.
On deer I've actually had quicker kills and larger wound channels with PRB than with REALs or any other conical. The PRB is a lot more prone to expansion, and if you want to call a quicker kill knockdown power, I'll agree with you.
The REALs and other conicals might be the order of the day for Texas heart shots on deer, but I don't take those. I've only recovered two PRBs from game (a moose and an elk), and no conicals. Entrance and exit from conicals were basically the same. Exit holes from PRB definitely show expansion.
I don't see any reason not to use REALs, but for broadside shots at deer, I'd be extra careful about what was behind them. That conical is going out the far side with enough geewhizz to do lots of damage to anything else in the way.