one of the fun parts of muzzle loading is that you are in charge of your load's various components: the thickness of the patch, the patching material, the type and consistency of the patch lube, the diameter of the ball and the amount of powder used to propel the whole mess downrange.
each particular gun has a 'sweet spot,' where all these variables come into tune. (all rifles are, at the end of the day, resonant mechanism: they requite tuning, just as you would tune a piano or an internal combustion engine).
as a general rule, if you have a higher rate of twist, the zone of the sweet spot is narrower, thus:
in my one in 48 twist Thompson Center, if I vary the powder load weight by five grains, I will start to open up the group noticeably. However, in my Colerain 1:60, I can get away with a ten or twelve grain variance before things start to get sloppy. (remember that this is a volumetric measure, by the way)
I don't know why this is, but it is.
Other points to ponder: all guns have their own unique 'best load.' I doesn't matter is it's the same caliber, the same manufacturer, the same powder, ball, patch and so on... you have to work up a load for each of your guns.
For the best way to do this, I recommend Dutch Schoultz' method. This is far and away the best shooting accessory you can buy without a permit. here's a link:
http://blackpowderrifleaccuracy.com/
good luck in your quest for tiny groups, and
Make Good Smoke