I've shot American Pioneer Powder, Pinnacle, Pyrodex, and Triple Se7en out of a number of my traditional rifles as well as countless pounds of Goex, Swiss, KIK, and once some Elephant.
I discovered that some of the rifles really do shoot well with substitute powders. Whether they shoot better with the substitutes over the black powder, only your rifle will know. I have one .54 caliber that shoots its very best with Triple Se7en 2f. Because of the increase in accuracy over black powder with it, I used it deer hunting one season and the two deer never knew the difference.
I shot Pinnacle 3f out of a .58 caliber with results hard to beat. Yet Pinnacle shot terrible out of a couple of my .50 caliber hawkins when compared to Goex.
You still have to clean the rifle at the end of the day. You will see a reduction in fowling simply because of the nature of the beast between the two kinds of powders. In fact I just got my first pound of Shockey Gold and Black Mag 3 two weeks ago. I have not had a chance to shoot them yet, but look forward to the opportunity to experiment with them and my rifles.
Good luck with your testing of different powders.