Excellent insight in that, Trench. I almost never set up the chronograph any more and simply look at trajectory or point of impact at various ranges to decide how much is "enough."
For my needs, I always sight in a big game rifle at 75 yards. With 80 grains of 3f from my usual 50 cal (39" barrel), that puts it roughly dead on at 25, an inch high at 50 and 2-3" low at 100.
I was setting up a short, light 58 cal for this year's hunt and it was real fond of 80 grains of 2f, but getting a little "starchy" with 100 grains. When I sighted in at 75 yards it was close to 3-4" high at 50 and about 6" low at 100.
That's waaaaay too loopy for my needs, so I bucked up and increased the charge to 100 and sighted it in again at 75. Now it's right at 2" high at 50 and only 4" low at 100. That's fine for my needs, and I found a "sufficient" charge for my needs without breaking out the chrono.