If your concerned about pressures, use a smaller powder load. IMO, the small difference that a vent hole in your clean out screw, or in the drum for that matter, will produce isn't worth the effort of putting it in.
I have drilled a 1/16 inch diameter hole in the drum of several CVA rifles, between the nipple and the barrel and angled slightly upward and forward but this was to improve the reliability of ignition with Pyrodex, not to reduce pressures. (Yes, it seemed to help).
I own a number of rifles which use a unvented side mounted drum and I have no concern about the safety or pressures at all.
If the threads in the barrel and on the drum are full threads, there should be no danger.
I say this based on the following:
The surface area of a 5/16 inch thread (fairly common for the drum to barrel threads) is .0767 square inches. A 90 grain FFFg powder load under a 245 grain Lyman Maxi slug will produce about 18,900 PSI breech pressure.
That much pressure acting on the area of the drums threads will create a force of 1450 pounds.
A 5/16-18 mild steel nut (basically the same as the tapped threads in the barrel) is easily capable of operating at a load of over 3300 pounds which is over twice as much load as the above slug/powder load will create.
By the way, the pressures for a .440 dia roundball with a 90 grain FFFg powder load (which IMO is a very "hot" load in a .45 cal gun)are about 16,200 PSI which will exert a force of 1242 pounds of force on the drums threads.
zonie
Pressures from Lyman Black Powder Handbook & Loading Manual