I guess it depends on what your primary use for the rifle is. For target shooting in a match and practice I usually try for the center of the 6 bull 8 ring black target at 25 yards. For me I am usually close enough at 50 with that. I usually up the powder 10-15 grains at 100 yards. Alot of people like to sight in using a 6 o'clock hold at the bottom of the black. I try to sight in holding center of target, in case I use that gun for hunting or shooting at animal paper targets. I know alot of people here will be much more knowledgeable on what I am about to say and can clarify me if I get something wrong here. Many years ago I heard of the 13 yard rule, which is actually for 12 1/2 yards but usually rounded up to 13 yards. Apparently the old longhunters and mountain men, knowing the trajectory of the roundball they fired, zeroed in using this method. As I recall once you have the correct powder, ball and patch combo zero in to strike 1 inch high at 13 yards. The ball should hit 2 inches high at 50, drop and hit poi at the center of the target at 75, be 2 inches low at 100 and 6 inches low at 130. That way when hunting or in battle they could hold center of target and get a lethal hit from the muzzle to 130 yards. As I said I may be off on this somewhat and others can correct where I misquoted. I have tried this a few times with my Early Virginia I got from Narrangansett over 20 years ago but didn't stick with it enough to work it out. I have not been to our muzzle loading club's range since my wife passed a little over 2 years ago but am really getting ready to get back out there and will probably try that with my Early Virginia again, hopefully seeing it through this time.