I hunt with either a 50 cal or 54 cal. From the 50 all I shoot are Hornady Pa Conicals with 90% of that gunk lube they use wiped off. For the 54 all I hunt with are Lyman 533-476, hollow base, Minie lubed with SPG.
Both barrels are GM with 1-70 (or thereabout) twist. Both the Pa Conical and the Minie have a hollow base to expand easily and engage the rifling.
Both are very accurate out to 100yds.
I use these types of conicals as for me, they are easier to load and reload than a PRB. I have a physical disability with my left arm\hand and find keeping a patch and RB aligned for loading more difficult that an "ordinary guy."
The deer die just like a PRB, but for me it's a matter of "it's just easier".
Here's the 54 cal shooting the Minie. 5 shot group, from a bench, 100 yards. BTW, for the Minie to "stay put" in the barrel, I've used a Lee Universal Expander die and have "bumped" the hollow base of the Minie to the diameter that is just enough for the Minie to stay put once shoved down the barrel. IF not, the Minie has a proclivity to not stay seated....which is fine if you're just loading, keep the rifle up or level and shooting. But for hunting that never happens.