I would suggest a conical for the 45 cal.
Folks hunt deer with 36, 40 and 45 cal PRB though and will likely crucify me for suggesting other than a PRB for the .45.
I'll be hunting deer this coming season here in MI with at 45 and I'll be using either the Hornady or the No Excuse conical.
The deer won't object to you being a bit less than "traditional".
If a conical was not available, the shorter ranges and excellent shot placement with PRB should previal. Shot placement should be there anyhow.
Or if you, your .45 and your deer wish to be traditional, try loading a slightly heavier charge using an over the powder wad.
Again, I would use a conical, chasing after a wounded deer is not my idea of fun.
www.hornady.com
Hornday Great Plains 45 CAL 285 GR HB-HP
http://members.aol.com/noexcusesb/page3.html
45 Caliber, 385 grain (45/385): Designed as a lightweight varmint/target bullet, when charged at 50-60% normal hunting load. When charged at that 50-60% they make an excellent target or youth load. This combination closely replicates a fully charged load behind a 460 grain "NO EXCUSES" bullet. It can also be used as a sabot in 50 and 54 caliber firearms.
45 Caliber, 460 grain (45/460): Designed as a big game bullet, it is very similar to the proven Pope design. It's accuracy and design have enabled shooters to harvest large game in excess of 300 yards utilizing it.
45 Caliber, 495 grain (45/495): Designed for large game including Elk and Moose. It's design (larger frontal diameter) provides for exceptional expansion and weight retention.
www.tcarms.com
45 Maxi-Hunter, 255gr, No. 7784
45 maxi-Ball, 240gr, No. 7794
:m2c: