My deer this year was a good sized mulie Doe taken at 75 - 80 yards with PRB over 60 gr (by volume) of fff. Ball exited the far side and made a mess of the lungs.
I don't know the velocity of the load, but the same gun made 1475 fps with an 80 gr charge of the same powder. The 60 gr charge was probably around 1300 to 1350 fps.
We don't need near as much powder to do the job as we seem to think. I'm NOT advocating light loads. Don't want anyone to think they should reduce their loads just because it works. OTOH, if someone has a physical condition that requires light loads or a gun that shoots particularly accurately with such, then there is no reason, IMO, not to use it.
Heavier loads give an accuracy advantage due to flatter trajectory.