Kirrmeister - As with others on this post, I too use conicals moulded in a Lee mould. I shoot these out of a Remington 1858 made by Pietta.
I do not use wads, but I am very careful to make sure I have plenty of lube in the two lube channels in the bullet to help prevent chainfires. I accomplish this by melting some bore butter or similar lube in a double boiler on the stove then use an oral syringe to put the correct amount into the lube channels. By the time I am finished with a batch they are cooled enough to put in my bullet holder.
I typically shoot 25 grains of FFF Pyrodex for target loads and 30 grains for plinking/hunting loads. I have never actually measured my groups, but it will shoot comparably to my .45 Sig, and .357 groups at the same distance.
If you are going to cast your own, be certain to use pure lead (which in the US is hard to get). If you use lead that is melted down from range collections or scrap lead it might have too high an alloy content and be tough to ram home. With the Remingtons I am careful not to stress the loading lever too much. I think the Colt 1860's have a more durable design that can stand up to the pressures better over time. The link in the Rems could wear quicker with harder bullets.
Hope this helps.