I have heard of and seen threads damaged in several ways.
There is the common "cross threading" that most everyone is familiar with. For those who don't know, if the male thread is started into the threaded hole slightly cocked it will act like it is engaging but it instantly becomes very hard to turn.
If it is forced the threads on both parts will be deformed and ruined.
Then there is "overtightening". This is a common cause of threads "wearing out" and becoming "loose" after the male part is installed and removed several times.
This (IMO) is the main cause of drums, vent liners and nipples "wearing out".
For the record, here are the recommended MAXIMUM torques for threads in mild steel (like your barrel and drum) parts.
1/4-20 = 57 Inch Pounds (4.7 Ft/Lbs)
1/4-28 = 77 Inch Pounds (6.4 Ft/Lbs)
5/16-18 = 95 Inch Pounds (7.9 Ft/Lbs)
5/16-24 = 103 Inch Pounds (8.6 Ft/Lbs)
3/8-16 = 172 Inch Pounds (14.4 Ft/Lbs)
3/8-24 = 196 Inch Pounds (16.4 Ft/Lbs)
If you are familiar with torque/load tables and you notice these values are reduced there is a good reason.
Normal thread installations are for static loads.
In your gun, there is also the pressure load during firing to deal with.
I have reduced the torque values to accommodate a breech pressure of 12,000 PSI so that the thread material will be able to accommodate these added forces without exceeding the yield strength of the barrel and drum, vent liner or nipple.
If these guidelines are followed the drum/vent liner or nipple threads can be assembled and disassembled hundreds of times and there will be no significant wear or loosening under normal fastener service.
Even you folks who aren't swapping locks and vent liner/drums should pay attention to the values given because whenever you replace a nipple, drum or vent (not to mention a breech plug) you do not want the torque value to use up all of the threads strength.
By the way, the above torques will be more than enough to prevent a drum, vent liner or nipple from "working loose" unless a "friend" grabs some pliers and tries to remove them.