First off, if the question to be asked is, "will it blow up" I am not trying it. That said, there are published loads for Titegroup, 45-70, 405 grain bullets. Max loads, IIRC, are 12 grains. [Don't believe me, look it up for yourself.] Period ! Not the whopping 80 they stuffed in that poor ML beast. I have shot many 45-70/405 loads at 10 grains and they are very mild. It is quite safe [Marlin 1895] in that cartridge bc Titegroup is position insensitive. But it still can be a dangerous practice bc of the small charge and the easier possibility of a double charge that would, most likely, be catastrophic. Will I attempt it in any muzzleloader ? Never, no way, no how ! Living with all my parts is still attractive to me.
I think if they really wanted to vaporize that rifle, a real tight double ball over 80 grains of imr 4198 would be interesting. I saw their full barrel BP double ball test and it looks to me like that could go either way depending on the rifle. You guys can try it multiple choice. SW