There are a lot of variables here. What is the depth of your rifling? What is your intended powder charge? Do you already have a mold and if not what are your options for a skirt thickness? Can you make a custom base plug for a mold?
Deep rifling, as for a patched round ball, would require a thinner skirt so as to expand into the rifling and seal. A heavy load needs a thicker skirt to prevent it being blown out when leaving the muzzle.