I am slowly learning that reaming the cylinder chambers is not a requirement. I recommend pressing a .35 ball into a chamber, removing it and then seeing if the diameter is larger than the bore diameter rifling of your pistol. If it is then you are probably OK. Attention to other factors for the reliability of the pistol should come first. Duelist54's videos on reducing cap jams is excellent. I have done this to my navy and have not yet had a cap jam since (knock on wood).I’ve long thought a Colt Pocket Police would make a nice little backpacking trail gun, but a lot of work would need to be done, including reaming and chamfering the chambers.
I don't have the money for 45D to do a workup on my pistol but I am intrigued by the use of coil springs for the trigger and bolt.