I have been hunting with my two 50 cal, TC Hawken and Traditions Kentucky, using 70 grains 3 f for some time. Always seemed right, the rifles like it. However, most of my shots have been under 50 yards. I now hunt where a 75-100 yard shot is not out of the question.
My longest shot was 110 yards at a very fat doe (she's the largest I've ever shot - I thought she was at 80 yards). I hit her broadside about 2" lower than where I aimed (distance you know). 70 grains of 3Fg and a 224 grain .530 round ball. Had I been using a 175 grain .490 ball the only difference would likely have been a bit less bullet drop because the .490 ball would've been moving faster than my bullet.
OH the ball went through her, broadside, taking both lungs out, and she went 20 feet and fell over.
I shot a large buck a few years back at about 55 yards...zipped right through him broadside, and he went for about 80 yards. He was, however, all hopped up on adrenaline as he'd been harassed by some foxhounds from the adjacent property, and wasn't running when I shot, but had just slowed down, and then stopped for a moment to look over his shoulder to see if the dogs were coming over the fence in the distance to his rear (his mistake was halting). My point is even when you have enough umph, the deer might not know it's "done" and might make for an interesting day, finding it.
This year's deer was at 62 yards, went through her too....,
So the ONLY thing you need to do, since your hunting situation now has increased range, is to a) shoot some targets at 70 or 80, and 100 yards, to see how the impact
from your rifles changes at those distances, and b) figure out some known landmarks or make some, from where you're located to various points so you know the distances to the deer when you see them (imho).
LD