I would suggest that once you get the gun sighted in that a 75yd limit is a good outside range for that cal with the larger deer and PRB, the one thing that I have seen to be the biggest problem with using the ball for hunting is taking to long of shots, this even spills over to the modern comical bullets from what I have seen when helping people try and find heir game later the same or on the next day, when we go to where it all started and they say I was here and the Deer was up/down by that snag, most of the time when asked how far they thought it was they greatly under judged the range or just thought that 125-150 was OK even though no practice was dome at that distance and likley no practical vision of the sight picture was in mind, it CAN OK be if both gun/ shooter/load are up to it but it is best to error on the side of caution there will always be more Deer if one chooses to let a few walk, good luck and enjoy the journey.