I've killed two deer with muzzleloaders that were shot in the neck - the deer, not the rifles. Okay, here's the punchline; both were by accident. One was moving and I over lead him, the other twitched as I touched the trigger. they were both close shots, too, and died in their tracks. The only deer (1) I ever shot in the neck on purpose was shot with a modern rifle.
I always aim for the heart/lung area but in an emergency would go for the liver (haven't had to do that yet). If a deer were really close, say, not over 15 yards, I would shoot the neck if it were the only chance I'd get (hasn't happened yet). So then, except for a couple of accidents, I've yet to aim and shoot the neck.