Rick: For your .45 cal gun, buy some .440 diameter and some .445 diameter round balls. Hornady and Speer both make them.
Buy several different thicknesses of patches made for .45 cal guns. A good starting thickness is in the .012 to .018 thickness range.
Thicker is usually, but not always the best choice.
If you buy the pre lubed patches, your on your way.
If you buy some unlubricated ones you can buy something like Bore Butter or TC1000, or just make your own lube from Stumpkillers recipe for Moose Snot or just use spit to lube them.
Start with a powder charge of around 45 grains and work up from there. .45 caliber guns seem to like FFFg or Pyrodex P best. The finer powder burns cleaner in these small bore guns.
If your gun is a flintlock, forget the Pyrodex. It works VERY POORLY in flintlocks.
It is impossible to say what your gun will like best, but somewhere there is a ball size, patch thickness and charge weight that will produce very accurate shots.
finding that combination is all part of the game, and it gives you a good excuse to go out and shoot some more.