The 1-26 twist is way too fast for a patched round ball except with a very light load, the round ball will not hold the rifling. To get a round ball to stabalize in a fast twist barrel is a matter of reducing the charge till the ball doesn't jump out of the rifling (strip the bore). I think you would be down under 30 grains by then. A solid pure lead conical such as Conical Bullet, .50 caliber, 410 grain, hollow point, flat base, swaged and lubed, 20 per box, by Buffalo Bullet Co . Such a bullet with a 60-80 grain load the ballistics should be fine for large game. The real trick is in sizing just right for a tight fit an over powder wad is a good idea too. The solid lead hollow point with have much better performance at the target than the jackected pistol bullet in the unmentionable. There are a lot of .50 bullet moulds around for various weights and also a lot of custom casters who can supply pure lead conicals on request for a lot less than the 20 per box stuff commercialy available. Of course you have to be up for the experimentation.
Bob