As stated a grain per caliber is a good place to start. Accuracy is more important than maximum velocity. Try three shot groups as you work your way up on the charges. Remember only change one variable at a time as you try for the most accurate powder charge, ball size, patch thickness, and lube. .440 balls are most often used in 45 calibers, though some like a .445 ball. .015 thick pillow ticking is a good starting point on patches. You want as tight patch and ball combination as you can easily load.Remember exact components isn't as important as consistantcy. I was once at a trail shoot that was won by a man using an old T shirt for both shooting patches and cleaning patches!The Dutch Schultz method will save you a lot of time playing around. Dutch has made shooting consostancy a simple process.