I'm a NRA Distinguished Expert. I use wads for both PRB's & 370 grain Maxi's in my .50 caliber "48-twist" rifle. Depending upon temp & humidity, I lube the wads. Using a well-lubed wad keeps the fouling soft enough to shoot all day without wiping, lowers the sdv (thereby improving accuracy), protects the patch or the base of the Maxi against too hot a burn causing a deformity, and tightens groups.
Back in October of 2009 I suffered a small heart attack & received (2) stents. Wife didn't want to let me shoot, but "caved-in" when I told her I would have friends lift my shooting box outta the car, so I went! I used an Ox-Yoke .50 caliber pre-lubed wonder-wad on top of 72 grains of 3Fg Goex black powder & then my 370 gr. T/C Maxi-Balls. At 50 YARDS, all 5 shots went into the 10-x Ring of a B-6 50 yard slow-fire pistol target. The wads did their "thing", lol!
Good luck & continued success!
Dave