What time period are you wondering about? Earlier Southern guns often have a mix of German and English features and alot of times leaned more heavy toward the English - use of English locks, carving based on typical English work of the time period, cheekpieces generally less prominent than what you'd expect to see on an American rifle with a lot of Germanic features, etc.
In the earlier days there were guns made in Virginia by smiths who settled there originally and others by gunsmiths who came from the North, all had different influences and there's a wonderful diversity to the work they turned out. There is no one "Virginia Rifle" so to speak, sometime check out Rifles of Colonial America vol 2, there's a section on guns of the South that would give you a good idea of what we're talking about.
