Inside 50 meters, a PRB will kill a deer with any good, well placed hit to the heart/lung area. And the ball usually complete passes through the deer, leaving a much larger exit hole than the entrance hole. I consider the .45 a more than adequate deer caliber out to 75 yards, and it will kill well past that range. The difference between recovering a dead deer, or not, when shot at 100-125 yards depends on the skill of the hunter in tracking wounded deer. The deer will die. It must may travel 50-100 yds before doing so. I have had to track down deer for hunters that I found well within 50 yards of the place where the animal was standing when shot, but which the hunter " lost ", al because the hunter had no clue what a deer's footprints look like, much less have any elementary training in tracking game animals. On one track, I showed the hunter where he stepped right over a half dollar sized spot of blood, with his own bootprints visible in the wet leaves next to it. The young man was so confused I took him back to the place where the animal was standing when he shot it, showed him the fur from the off-side where it hung up on brush, and then turned him around so he could see the tree he fired from. He had shot a nice 6 point( Eastern Count) Buck.