First, welcome to the Forum! To answer your question, yes it can be done, however it's not recommended! Most all of us here on the Forum that use C&B revolvers, do so with the use of an over-powder wad known as a "wonder-wad". The are caliber specific (.36, .38, .44&.45 same wad) and come pre-lubed to help soften-up the fouling in the barrel so as to maintain accuracy during a match. Ox-Yoke, RMC and other companies make them in various sizes.
Here's how to use them: First pour in some powder (20-25 grains, more for bigger guns like the Colt Dragoons), then put a wonder-wad into the chamber over the powder, then put the roundball over the wad. Then use the gun's rammer to squeeze it all together, being careful to use the same amount of force to obtain the same depth on each chamber. This will insure more accuracy shot to shot. Most wheelgunners have a custom loading stand to help them with this project. I do and mine was made by a very good friend. The uniformity and consistantcy that one obtains from the use of one of these stands can't be duplicated!
Whatever you do, DON'T ever put a wad over the top of the ball. The wad could get hung-up between the cylinder face and the forcing cone (due to recoil) as the wheelgun comes into battery, resulting in a jam and possibly the need to disassemble the gun at the range to clear the jam!
Enjoy making smoke and remember to always be safe and use the wads! And welcome again to the Forum!!
Dave