Capper, I have the same problem with the Remington grip, it squeezes the second knuckle of my second finger up into that wedge between the grip frame and the guard. It's uncomfortable just holding the gun, much less firing it, it seems like the weight of the gun is resting on my knuckle. I have modified the guard on a couple of them by cutting out the rear portion, turning it around and soldering it back in to make a square back guard. That provides enough knuckle room.
I've owned quite a few Remington types over the years and they all were accurate but the only C&B revolvers I still own are Colt replicas, a .36 caliber 1851 and a .44 caliber 1860. Between those two it would be hard to choose but I do prefer the longer grip of the 1860 and would be more of a factor to me than the caliber. The .44's are a bit more powerful but I don't hunt anything larger then rabbits with C&B revolvers and for that even a .36 is overkill.