I've tried this quite a bit in 50, 54 and 58 caliber and always found it more of a "concept" for using a single powder measure for multiple purposes, rather than a ballistic fact for any rifle I've ever owned or been around.
I'm yet to meet a 50+ caliber rifle that didn't absolutely love 30 grains of powder for small game shooting, but as caliber goes up above 50, the utility goes down for using two scoops from that measure to generate a big game load. In fact I prefer something on the order of 80-90 grains in 50, 90-100 in 54 and 100-120 in 58 for trajectory and whomp. But if I halve any of those charges for a measure to throw small game charges, the loads are just too darned hot for the purpose.
Move down to 45 caliber and below, and maybe things get sweet for using a single measure for both loads but I just can't say. There's a 40-45 caliber "hole" in my lineup of rifles, and I don't load heavy loads in my 32 and 36 caliber rifles, since they're small game-only in my life. And as a matter of fact, my charges in those have slipped down below 20 grains for ideal small game performance.