Yes, it can be done. Depends on how good you are. A .50 prb over 50 gr fffg should be sufficient, but you must get a heart or lung shot. I personally wouldn't take such a shot. .50 cal/50 gr is the very bottom of what you need for a short range whitetail shot; ten grains less is not good enough, and whether you can shoot that gun accurately with a heavy load like that is questionable. I can't, even at 25 yards.