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will a round ball work out to 150 yards? Or is the conical the better choice for that..?
Assuming by work you mean kill game like deer, a round ball of sufficient weight/diameter will work out to 150 yards. For me, that definitely does not include the .45 caliber, and even the .50 is marginal at that distance. Personally, I limit round ball shots on game with a .50 to 100 yards. I'll take longer shots with the .54 and .58 but to go out as far as 150 yards conditions would have to be absolutely perfect - broadside shot/relaxed and still animal/no wind/good rest/good light.
On the other hand, I will not hesitate to take a 150 yard shot on a deer with a 350 or 465 grain conical in my .45 Green Mountain barrel. For me, a conical is clearly a better choice for the hunter wanting or needing to shoot beyond 100 yards.
Will a 450 grain conical 45 bullet fly and hit like a 450 grain 54 conical...? Or does the diameter of the 54 have an advantage..?
Given equal weight, the .45 bullet will have a significantly better ballistic coefficient than will the .54. If both are leaving the muzzle at the same velocity, the .45 will have a flatter trajectory and will maintain velocity and energy better.