Thanks for all the interesting info, gents. As mentioned up above, this will be a meat hunt, so the bison will be probably half the mass of a fully mature one-ton big boy. It'll still be one of the biggest critters I've ever shot, and by far the largest I've taken with a muzzleloader. It looks like a .54-cal PRB will do the job, and I don't intend to shoot beyond 50 yards or so.
I'm just more accustomed to having people tell me that my gun choice is overkill, rather than wondering if I'm using enough! :grin: :haha:
Unfortunately, it's starting to look like getting the meat back into my country is going to be much more difficult that I imagined. I'm still researching that end of it.