There's a few ways to do it:
TARGETS - When loading up and practicing for the NE Flintlock Championship that shoots targets @ 25, 50 & 100-yards, all offhand, I had 2-loads with my 50cal flint longrifle. One was a lower/lighter charged load that was dead-on @ 50-yards, and that load was used @ 25Y, whereas I can hold off as may be needed for the closer target, and the hold off was barely 1/2" ... or actually closer than I can really see, LOL!
I had a heavier/faster load that was then dead-on @ 100-yards, and that process must have worked, as my 100-yards scores - for all the targets shot @ 100 - for the past 2 annual matches have been 1st place or only 1-point behind the 1st place score, but never lower than 2nd.
HUNTING - Sight in for 50 or 75-yards, whatever YOU think YOUR woods will accommodate best, plus using your most accurate load (see my many posts on how to do 'load development'). But here's an option used all the time to extend your range ... just raise the front blade 'up' in the rear sight notch.
I do this all the time and it becomes 2nd nature, as using that same 50-cal longrifle, I can
ring the 10" diameter gong set out @ 200-yards with just about every shot ... as I don't think I've missed yet since establishing my hold/sight picture ...
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