In 1965 I obtained a Navy Arms 1851 Colt & a 5 lb bag of 00 buckshot. No instructions, so no grease or anything in chamber but powder & ball. Shot about 800 rounds that summer working in the woods, & had no chain fires.
Since then I've shot 1000's of rounds through the dozen or so revolvers I have/had with only one causing chain fires. That was a cheap Italian 1851, and it did it twice. After the second time I got rid of the pistol, so don't recall the make. I know this is a common topic, with lots of theories, but I believe a lot has to do w/ how the cylinders are bored, thus the problems w/ individual pistols.