Grant: I have found that You can use Either FFg or FFFg powder in guns, depending on what the guns shoots the best. You have to TRY them both in your gun, working on loads to see what seems to work best.
The main reason people seem to use FFFg powder is because it supposedly fouls the barrel less. I found that when I screened FFg powder to get rid of both the larger pieces, and the fines, I get clean burning and no more fouling than when using FFFg powder. I also got more consistent velocities from the screened powder than from unscreened.
To really know what your gun likes, I recommend using a chronograph. That way, if you have a particular load of FFg that seems to shoot very well with FFg, you can reproduce that velocity with FFFg powder, exactly, to see if the finer grade powder provides the same accuracy, and if it then offers other benefits to you over FFg.
In a 37 inch barrel, my brother's percussion .45 rifle shoots both 65 grains of FFFg powder well, and a lower charge of 40 grains of FFFg powder. I believe he is going to use the lower charge for targets at 25 and 50 yards, and leave the heavy load for targets that are at 100 yards and beyond.
He has not tested FFg powder, but I think I will convince him to do so, particularly with the heavier load, as it not only barks at the muzzle, but at the butt, too. Its not something that is disturbing each shot, but the cumulative effect over many shots begins to wear him down a bit.