Its all the same powder.
As we know, when a manufacturing run (LOT#) of BP is made, it ends up being broken into many different size granulations and they're screened off into different storage areas...but all the kernels of BP are the same chemical composition.
The smaller granulations simply burn faster (and cleaner) generating a faster rising spike on the pressure curve...but its the same powder...if I normally use a max load of 2F, I reduce the 3F substitute charge by 10-15% to keep the pressure in the same ball park.
For example, I recently sighted in a .58cal load using 100grns Goex 2F...then test substituting 90grns Goex 3F I got almost the identical POI...1/4"-1/2" higher than the 100grn 2F charge at 50yds...and I know from past experience if I don't want to change the sights, I can drop down another 5grns of 3F to 85, and the POI will be right on that of the 100grn 2F charge.
Its all the same powder...just need to manipulate it accordingly when changing granulation sizes...make an appropriate charge of 3F to duplicate and/or improve upon a charge of 2F.
I found 3F to be more accurate in .40/.45/.50/.54/.58/.62cal rifles and in .28 & .20ga smoothbores as my shot loads actually pattern better with 3F.
I've also seen an Internet article or two allegedly quoting some old time smoothbore shooters that with its faster ignition, burn time, and velocity, 3F gets the payload out of the barrel sooner which helps wingshooting but I have no personal knowledge or official source for that.