It may not make a difference in a .22 LR casing, but it does in a .38 spl. casing. placement of the powder seems to be the one explantion for some of the ruptured casings and cylinder walls on revolvers, that has withstood testing, using verified small amounts of bullseye.Its believed that the high pressures are a result of two pressure waves hitting each other, when the powder is out against the bottom of the bullet, and burns, producing one wave that now heads back toward the base of the casing. At the same time, the primer also prduces a shock wave that is racing toward the base of the bullet. The two meet in the middle, and act as an overload, bursting the casing, and usually the chamber. When the powder and primer are together, they produce one pressure wave that is going towards the base of the bullet, and pushing the bullet down the barrel. This doesn't happen in these casings when you use a bulkier powder that fills the case batter.
In a BP gun, a little air space can go a long waay, depending on caliber, and the powder charge used.
I recommend seating a ball in all flintlocks so that it just touches the powder charge, so that there is loose air in and around the granules of powder behind the ball, and the powder is not compressed.That practice produces the lowest SDV. In Percussion guns, you get the lowest SDV doing the OPPOSITE. Compress the powder in a cap and ball gun. The more consistent the compression, the better the SDV. I also recommend using FFg powder in flintlocks, regardless of caliber, while using FFFg in all percussion guns, regardless of caliber. The larger granule of powder burns quicker over all in flintlocks, because the extra air between the granules helps internal ignition. In Percussion guns, the small sized granules pack together better, and the percussion cap burns a hole right through the entire powder charge, to ignite the whole thing off fast, and consistently. Hence, the smaller SDV.