With 48" twists, you are much better off with a very short-for-calibre bullet. Just as Maxiball says, the heavier, therefoe the longer the bullet, the poorer they shoot.
; By all means, go with a Lee REAL slug if you want to cast your own, & their moulds are cheap. If you want to buy slugs, try the Bal-ets. They come pre-lubed and shoot well in my .45 cal rifle.
; In the .50 cal, try to keep your bullet weight below 325gr. 48" is too slow for proepr stability of slugs, but too shallow in depth for round ball shooting with heavy loads. Some will shoot patched round balls very well, as do Maxiball's 48" twist guns. They require very snug combinations to do well, due to shallow rifling, but will do just fine on deer. The first 8 deer my bro shot with a smokepole were with a TC Hawken Flinter in the early 1970's. He used a .495 ball, .018 patch, 85/90gr. 2F C&H and dropped them in their tracks. Slugs rarely do that with the same lung hits.
: Some slugs, due to their nose shape are poor game killers. The TC maxiball is one of these. Due to the sloping shoulders, and large, deep grease grooves, the maxiball seems to collapse instead of expand and it makes a fairly neat wound, opposite what is desired.
; REAL bullets, similar in nose shape, lack those deep grooves and seem to work well on deer.