Yes. I have even noticed a difference in cans of powder change. Not much, but some. I cannot comment on the differences in BP brands. As I have said I find it extremely accurate for TRIPLE SEVEN if you add 10% to velocity and pressure. That I have validated with at least a hundred of chronographed rounds.One thing I did notice on the data sheet work up…it was for Swiss BP. I can take the same weight charge of Swiss and Goex in my 50 caliber longrifle, and the Swiss will have a 25 to 30 percent velocity increase over the Goex. That could make quite a difference.
Again, take the external ballistic chart and use it to validate the internal ballistic calculations. Add or subtract powder to give you matching sight in and various drops at ranges.
It takes some stubby pencil work, some meticulous records, and some chronograph work, but once you have a load worked up and know it's capabilities in your gun then you get to do this: