When I clean a percussion gun, I remove the nipples - even for a revolver. I inspect them and clean them using a pipe cleaner. If all looks well, and there is no mushrooming beginning to start, I reinstall them - using anti-seize on the threads.
Tighten the nipples snug, but not tight. They tend to tighten while firing.
For modern reproductions, I follow Cynthia's suggestion - replace them immediately. I have experienced brand-new Italian repro revolvers with nipples so over-tightened, I needed to use easyouts to loosen them. Best to get them out before firing the gun.
I, too, like Ampro nipples - but I have a couple of old, original guns on which I wouldn't like the looks of a brass-colored nipple.