If the gun is a percussion rifle, then load the ball with whatever pressure you think you can consistently put on it. Chronograph results show that consistent, but firmly packed powder( as is being done in Black powder Cartridge shooting) seems to produce the most consistent velocities.
If, however, you are shooting a flint rifle, I recommend loading the ball to a mark to just touch the powder. Chronograph results show the lowest SDV doing it this way, although the velocity is approx. 20 fps LESS than if you compact it. That can be easily overcome by adding a little more powder.
It is the deviation in velocity that is the prime cause for opening groups, although if you are not benchrest shooting that gun, you may never notice. At longer ranges( 100, and 200 yds) a PRB is so affected by slight changes in wind, that any difference in group size resulting from a low vs. higher SDV is negated quickly by the wind.
The slug gun shooters, using conicals, are the guys that have proven the wisdom of loading flntlocks differently than percussion guns, as they are different ignition systems, that just happen to both shoot black powder. Trust me, I started out with a percussion rifle, and then converted it to flint. It took me more than a year to accept the fact that I HAD TO DO THINGS DIFFERENTLY in loading the gun now that the barrel was attached to a flintlock, instead of a percussion lock, to get the same groups and accuracy, after the change. It then took me more than 5 years to figure out all the things that were different, one at a time. MY problem was, like so many of us, I just did not want to believe that changing something I learned to do shooting the same rifle in percussion, would make a difference now that it was a flintlock. If I was not so stubborn, I might have learned that a lot quicker.
NOW, I am being accused of being the wacko around hear because I am letting out all those secrets I have learned shooting flint. I don't blame anyone who doubts my advice. I was there WAY BEFORE they were. And, I don't mind the criticism. I am still reviewing the data, still tweaking this, still trying that. Any time I read a good idea here, I make a note and try it out at the range, or at least make a note to try it out at the range. I am backed up on getting to the range enough these days.