I think that Musketman is pinging on target here with his comments about burning time of powder in the barrel.
Somewhere in the distant past I remember reading that the greatest accuracy was achieved with a charge of powder which had expanded the gassess released with burning/exploding just as the ball reached the muzzle. If the gassess had expanded to the maximum with the ball any distance still down the barrel,then friction would start dragging the ball and ball drop would start earlier affecting accuracy. If the powder gassess were still expanding as the ball left the muzzle,then the expanding gassess would possibly give the ball a little wobble with uneven pressure on the backside. This made sence to me years ago when I first read it,and it still does. I think when we work up a load and get to the point where the ball is right at the muzzle when the gassess have expanded to the maximum then we have reached that magic spot! Other factors affect accuracy also for sure....sight radius et al. Just my thoughts.