There is no way I would consider this pistol a pip squeak. The fifty cal prb weighs in around 180 grains. The Lyman handbook shows data for the 45 Ruger New Army with a conical weighing 185grs, and with 35 grs of fff has a velocity of 905 fps. Now it has a 7 1/2" tube, but lose some vel for the shorter bbl, and gain some for the increase charge, and the velocity will be pretty close I feel.
JW Boothe's derringer was a 41 cal I think, which used a prb around 100 grs.
Come to think of it, 180 grs at around 950 fps is what most cops carry on duty, and it seems to work fine.
Eterry