Great video on YouTube by a guy, who gives a viewpoint I never thought of.....when gun makers bore the chambers they sometimes get "chatter" or run out on the tool, especially if the boring tool isn't brand new and it makes a very slightly out of round chamber that will allow some flame in.
Also another article stating that sloppy chamber filling may leave a fine trail of powder granules leading down past the ball, leading to a flash over.
The writer of this article claims that putting a slight hand chamfer on the chambers will help the ball seal the chamber better.
Overall, most of the people I've read about who have had chain fires usually get them in the chamber next to the fired one, and the balls blow harmlessly out the chamber. The short chamber doesn't give the ball a lot of time to build up a lot of power so unless the chamber facing the loading lever goes off the gun is usually ok.