With everyone understanding that when I say "grains" here I am speaking of grains as measured by volume using a suitable black powder powder measuring device I'll give a few numbers out of the 2nd Ed of the Lyman Black Powder Handbook and a .45 caliber gun shooting patched roundballs.
The barrel has a 1:48 twist so the pressures will be a little higher than your smoothbore .45 will have.
GOEX Black Powder, 3Fg:
40 grains = 1324 FPS (Feet per Second), chamber pressure = 5,400 PSI (Pounds per Square Inch)
50 grains = 1469 FPS, 7,600 PSI
60 grains = 1614 FPS, 9,800 PSI
70 grains = 1691 FPS, 11,100 PSI
80 grains= 1768 FPS, 12,300 PSI
PYRODEX P
40 grains = 1471 FPS, 7,400 PSI
50 grains = 1604 FPS, 9,200 PSI
60 grains = 1738 FPS, 11,100 PSI
70 grains = 1864 FPS, 13,800 PSI
80 grains = 1990 FPS, 16,500 PSI
This information seems to indicate that at the Pyrodex does generate higher pressures and corresponding higher velocities for a grain to grain comparison.
As for safety, your .45 caliber gun should be able to withstand any of the pressures indicated above with room to spare.