IMO, plugging the vent hole while you load the powder charge can be a good thing if the hole is going thru the barrel wall directly into the powder charge.
On the other hand, plugging the vent hole can be one of the worst things you can do if the gun has a Patent breech or one of the other style breeches (chambered breech) which have a long flame channel hole connecting the breech of the barrel with the vent hole location.
With these Patent or chambered breeches the loose powder has to get down thru the flame channel hole all the way to the vent hole for the gun to work.
If the powder gets hung up part way to the vent, when the priming powder in the pan flashes, there's no new powder in the area for it to light.
If that vent hole is plugged on a Patent or chambered breech gun, the air that is trapped under the ball will escape slowly past the plug in the vent. The slow moving air cannot blow the loose powder down thru the flame channel.
If the vent hole is left open, the air under the ball will be blown violently thru the flame channel hole and it will blow the loose powder thru the flame channel so it will end up sitting at the vent hole waiting for the pan to flash.
I agree with the others that say the vent liner should not be removed. Even for cleaning the gun.
Using a wire to "pick the vent" is all that should be needed to make sure the pans flash has a direct shot into the new powder charge.
I've found that normally even this is not required. When the gun fires, the blast of flame and gas out of the vent hole is enough to blow any obstructing matter well clear of the hole.
Oh. I should mention one thing that can cause all sorts of problems.
If the shooter pumps the ramrod with a cleaning patch on it up and down the bore to "wipe" the barrel between shots, all sorts of fouling will end up plugging up the vent hole.
If this happens then picking the vent before priming the pan is necessary.